| # | Children | Name | Born | Died | Father | Mother |
|---|
| 1 | Yes | | b. 13 May 1844 | d. 9 Nov 1892 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 2 | | | b. 2 Feb 1846 | d. 5 Aug 1850 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 3 | | | b. 17 Sep 1847 | d. 22 Jan 1927 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 4 | Yes | | b. 13 Feb 1849 | d. 24 Jan 1895 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 5 | | | b. 9 Nov 1851 | d. 3 Dec 1920 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 6 | | | b. 29 Jan 1853 | d. 5 Aug 1904 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 7 | | | b. 14 Nov 1854 | d. 20 Jun 1923 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 8 | | | b. 25 Nov 1856 | d. 11 Mar 1858 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 9 | | | b. 4 Jul 1858 | d. 12 May 1859 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 10 | | | b. 16 May 1860 | d. 9 Feb 1906 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
| 11 | | | b. 4 Jul 1865 | d. 22 Oct 1929 | His Grace John Winston SPENCER-CHURCHILL, 7th Duke of Marlborough, KG, PC | Her Grace Frances Anne Emily VANE, VA |
1822 - 1883 (61 years)