| # | Children | Name | Born | Died | Father | Mother |
| 1 | | | b. 30 May 1782 | d. 1 Oct 1845 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 2 | | | b. 29 Jul 1787 | d. 13 Apr 1870 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 3 | | | b. 1789 | d. 1791 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 4 | | | b. 1791 | d. 1830 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 5 | | | b. 1792 | d. 1792 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 6 | | | b. 1793 | d. 1793 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 7 | | | b. 1794 | d. 1823 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 8 | Yes | | b. 14 Apr 1798 | d. 27 Dec 1858 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |
| 9 | | | b. 1799 | d. 1864 | The Rt. Hon. George John SPENCER, 2nd Earl Spencer, KG, PC, DL, FRS, FSA | Lavinia BINGHAM, Countess Spencer |